Abstract

Background: Ventilator-associated pneumonia (VAP) caused by non-fermenting Gram-negative bacilli (NFGNB) poses a significant threat in intensive care units (ICUs), contributing to elevated mortality and morbidity rates. This study aims to characterize the multidrug resistance (MDR) patterns of NFGNB implicated in VAP. Methods: A cross-sectional analysis was conducted among VAP patients admitted GSMCH, Pilkhuwa. Antibiotic susceptibility profiles were determined using the minimum inhibitory concentration (MIC) test via the broth microdilution method. Results: Patients were categorized into infected and non-infected groups based on culture results, revealing that 37 patients (18.5%) were infected. Among the 37 microbiologically confirmed VAP cases, 17 NFGNBs (11 P. aeruginosa and 06 A. baumannii) were identified as causative agents. Specifically, MDR NFGNBs included 05 A. baumannii and 09 P. aeruginosa isolates. Resistance rates among P. aeruginosa were notable, with resistance observed against all aminoglycosides, ciprofloxacin, ceftazidime, cefepime, colistin, and imipenem. Similarly, A. baumannii exhibited high resistance rates, particularly against aminoglycosides, ciprofloxacin, ceftazidime, cefepime, colistin, and imipenem.

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