Abstract

To analyse the expression of VEGF in human breast cancer; to correlate the expression of VEGF and tumor grade in breast carcinoma; to assess the clinical significance of VEGF as a predictor of aggressiveness of breast cancers. Methods: This was a prospective study. 59 cases of radical mastectomy received for routine histopathological evaluation (after the histological sections were stained with H and E stain) in the Department of Pathology, MGM Hospital, Warangal, India, from June 2019 to November 2021 were studied. Results: All breast carcinoma cases were subjected to VEGF immunostaining. In present study the commonest age group was from 41-50 years with majority of the lesions diagnosed as IDCC NOS. Females contributed to large number of cases (57) in the present study. Majority of cases (59.6%) in this study are poorly differentiated breast carcinomas. VEGF expression was seen in 52(88%) cases. Of the 52 cases, 16 (80%) of the breast cancers were highly differentiated, 14 (87%) were moderately differentiated, and 22 (91%) were poorly differentiated. There is a significant correlation [P< 0.01] between VEGF expression and grade of breast carcinoma but there is no significant correlation is observed with variables like age, gender, tumor size. Conclusion: Recent results suggest that VEGF expression could both be considered as independent prognostic factor associated with unfavourable clinical outcome in breast carcinomas and that their expression is higher in high grade variants in comparison with low grade.

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