Abstract

NSTE-ACS are associated with a systemic inflammatory response that may accelerate coronary atherosclerotic processes. This study aimed to evaluate the impact of short-term treatment with colchicine on endothelial function in NSTE-ACS patients. Methods: All patients were subjected to history taking & physical examination. ECG & Echocardiography using conventional & tissue Doppler parameters were done to all patients, ESR & CRP were done at admission & 1 week after. All patients undergo baseline testing of endothelial function by using endothelium-dependent flow-mediated dilatation technique (FMD). Results: Both groups had similar ranges of relative FMD on admission. Group (A) had a range of 2.1-6.6 with a mean value of 4.42±1.07, while Group (B) had a range of 2.2-6.7 with a mean value of 4.54±1.18. After one week, both groups showed a slight increase in FMD values compared to admission. Group A had a range of 2.2-6.7 with a mean value of 4.54±1.18, and Group (B) had a range of 2.5-6.9 with a mean value of 4.36±1.14. After 3 months, Group A had a slight increase in FMD values compared to the one-week value, ranging from 2.3-6.8 with a mean value of 4.36±1.14. Group (B) also showed a slight increase in FMD values, ranging from 2.7-7.2 with a mean value of 4.86±1.55. Conclusion: Colchicine seems to slightly improve endothelial function in patients with NSTE-ACS assessed by flow meditated dilatation but this effect was nonstatistically significant.

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