Abstract

Hyperglycaemia in poorly controlled diabetes leads to production of advanced glycation end products and free radicals. Both can cause elevated collagen deposition in myocardium leading to myocardial fibrosis and thus effecting contractility and relaxation of heart. Hence a poor glycemic control can be associated with high chances of having left ventricular hypertrophy and left ventricular diastolic dysfunction (LVDD). So far, very few population-based studies have been carried out in India, to demonstrate the prevalence of diastolic dysfunction in diabetic subjects in the Indian patients. Thus, this cross-sectional study will be conducted with the aim of determining the incidence of asymptomatic LV diastolic dysfunction and its quantification on the basis of echocardiographic findings in newly diagnosed cases of type 2 DM subjects and its relation to HbA1c levels.

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