Abstract

The Nebulizer produces droplets of size 5-8microns, only 37-60% of the drug will be deposited in the oropharynx. Hence, significant side effects are not observed. It is a water-soluble molecule structurally related to Phencyclidine. It contains an asymmetric carbon atom hence has two optical isomers: the S (+) isomer and R (-) isomer. Benzethonium chloride is added as a preservative. The present study was conducted after receiving approval from Ethical committee of our institution. Following detailed pre-anaesthetic checkup, informed written consent was obtained from all patients fulfilling the required inclusion and exclusion criteria. On the day of surgery, after arrival to the operation theatre, the patients were shifted to anesthesia preparation room. Post extubation, 16 patients had cough in test group as compared to 18 patients in control group (p=0.068). At the end of 2 hours only 1 patient had cough as compared to 14 patients in control group(p<0.001). At 4 hours post extubation, no patient had cough in test group as compared to 9 patients in the control group (p=0.002). At the end of 6 hours, no patient had cough as compared to 2 patients in control group (p=0.153). At the end of 24hrs no patient in the test and control group had the cough.

Description