Abstract

The burden of cancer patients is on an increasing trend globally as well as in India. Systemic chemotherapy is the most common form of treatment for cancer. Laryngoscopy and intubation are nocuous stimuli that can cause intense changes in cardiovascular and respiratory function, through reflex responses. Lignocaine is an amide local anesthetic that reduces the stress response as a result of direct cardiac depression and peripheral vasodilatation. The higher dose of 1 mcg/kg was observed to produce an increased incidence of bradycardia and hypotension. Methodology: The study was conducted at a tertiary care centre on 219 patients who fulfilled the inclusion criteria. The duration of the study was from April 2018 to April 2019. Patients were randomly allocated in three groups and were administered their designated drug intravenously. Patients were intubated orally with appropriate cuffed endotracheal tube and tube position was confirmed by bilateral five-point auscultation and then connected to volume controlled mode of mechanical ventilation. Anaesthesia was maintained. Intraoperative monitoring was consisting of NIBP, continuous ECG, Capnography and SpO2. Result: Hypotension was seen in group B but not in Group A and Group C and this was statistically significant (p value <0.001). Bradycardia was seen in all three groups with highest incidence with group B followed by group A and then group C and this difference in distribution was statistically significant.

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