Abstract

The response to anesthetic induction and airway manipulation in the presence of cardiovascular disease and antihypertensive therapy has not been adequately investigated. Objectives: To study the incidence of hypotension during induction of anaesthesia in 60 hypertensive ASA II patients in the age group of 30-65 years on beta blockers (BB) alone or combination of beta blockers and calcium channel blockers (BB+CCB) until the morning of surgery, undergoing elective orthopaedic and general surgeries. To study and compare the hemodynamic effects of induction of anaesthesia in hypertensive patients on beta blockers alone or combination of beta blockers and calcium channel blockers. Methods: This was a hospital-based prospective observational study for a duration of one year at the Department of Anesthesiology, Government Medical College, and Thiruvananthapuram. 60 hypertensive ASA II patients between 30 and 65 years of age receiving beta blockers or a combination of beta blockers and calcium channel blockers, of either sexes, who were willing to be a part of the study and met the inclusion criteria. Results: There was a significant statistical difference between the two groups. 1 patient in the BB group and all 30 patients in the BB+CCB group developed hypotension, with an incidence of 6.67% and 100%, respectively (p value <0.001). There were 2 cases of bradycardia in both groups, which were not statistically significant. Conclusion: Hypotension requiring treatment in patients receiving a combination of beta blockers alone group 1 (BB), or combination of beta blockers and calcium channel blockers alone group2 (BB+CCB).

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