Abstract

Neonatal thrombocytopenia is common haematological abnormality and associated with severe morbidity and mortality in preterm neonates, so this study was conducted to find incidence of neonatal thrombocytopenia and associated maternal risk factors in preterm neonates admitted in N.I.C.U. Methodology: This Prospective observational study was conducted among 274 preterm neonates admitted in N.I.C.U., Department of Pediatrics R.D.B.P Jaipuria Hospital Jaipur over a period of 12 months. Exclusion criteria were Gross Congenital Malformations and birth injuries, maternal alcohol and abusive drug addiction and Neonates whose parents or guardians did not agree to be a part of study. Maternal and neonatal record files and charts were analysed and various laboratory tests were conducted as per protocol to obtain demographic, clinical and laboratory data. Results: Out of 274 study participants, 108 (39.42%) were having thrombocytopenia. Out of 108 cases, 58.33% were mild, 23.15% were moderate and 18.52% were having severe thrombocytopenia. Mean gestational age was 34.28±1.818 weeks in thrombocytopenia group. Mean total platelet count was 0.989±0.389 in thrombocytopenia group. There was significant difference in mean platelet count in mild (1.278±0.143), moderate (0.75±0.16) and severe thrombocytopenia group (0.376±0.065) (p<0.001). PIH and IUGR was significantly higher in thrombocytopenia group (p=0.012, 0.002). PROM was significantly higher in no thrombocytopenia group (15.06%) (p=0.049). GDM was more in thrombocytopenia group (12.04%) as compared to no thrombocytopenia group (7.83%) (p=0.342). PIH was maximum (40%) in moderate thrombocytopenia and minimum 11.11% in mild thrombocytopenia. PIH was significantly associated with severity of thrombocytopenia (p=0.009). GDM (p=0.085), IUGR (p=0.067) and PROM (p=0.919) was not found significantly associated with severity of thrombocytopenia. Conclusion: Screening of neonates for risk factors of neonatal thrombocytopenia for platelets count is beneficial in the early diagnosis and management of thrombocytopenia

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