Journal of Cardiovascular Disease Research
Inclusion bodies: A systematic review
Dr. Manas Bajpai
JCDR. 2021: 2230-2232
Abstract
Inclusion Bodies Inclusion bodies are dense, spherical, aggregated proteins, mostly formed in the cytoplasm of prokaryotes due to overexpression of heterologous proteins. A detailed description of the formation of inclusion bodies is reported elsewhere. Inclusion bodies reflect light and so can be visualized by phase-contrast microscopy. At high expression level, inclusion bodies may occupy about 40-50% of the total cell proteins. This research paper is an attempt to review various types of inclusion bodies in a systematic manner.
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