Abstract

To report the effect of Ivabradine, a non-selective HCN blocker on pain in a series of patients with radicular low back aches. Background - Neuropathic pain is one the most debilitating types of pain experienced among the various pain syndromes and is the most persistent complaint pain physicians observe. The augmented response and the allodynic features of neuropathic pain result from to spontaneous discharge of impulses from nerves, SSNRs, and DRG. This spontaneity has been attributed to pacemaker channels like HCN channels (HCN1-4). Ivabradine which is a nonselective HCN channel blocker was hence used to see its analgesic effects on neuropathic pain conditions like Lumbar radicular pain syndrome. Material and methods – A total of six patients were given Tablet Ivabradine 5 mg twice on days 1, 2, and 3 and their demographics, vitals, pain scores (like VAS, FPS, VDS), and complications were assessed at time point 0, 1 hour and 3 hours after ingestion of the drug. Result – Ivabradine as an analgesic showed insignificant improvement in the pain score in patients with Lumbar radicular pain syndrome and also caused marked complications such as symptomatic Bradycardia, hypotension, and palpitation

Description