Abstract

One of the major concerns in subjects undergoing laparoscopic surgeries is PONV (Postoperative nausea and vomiting). The use of intravenous dextrose to reduce PONV has controversial data in the literature. Aim: To judge the role of 5% dextrose administered perioperatively in reducing postoperative nausea and vomiting in laparoscopic surgeries. Methods: In 120 female subjects undergoing laparoscopic hysterectomy surgery under general anesthesia were randomly divided into two groups having 60 subjects each at beginning of the start of surgical closure Group I received saline for 2 hours at 125ml/hour and Group II received 5% dextrose at 125ml/hour. For all subjects, analgesic consumption, total rescue antiemetic, and hemodynamic parameters, and PONV scores were assessed. Results: Rescue antiemetics were needed in 63.3% (n=38) of study subjects of Group I and 26.66% (n=16) subjects of Group II. On arrival to PACU, PONV was significantly higher in Group I, 63.3% (n=38) subjects compared to dextrose group, 36.6% (n=22) subjects (p=0.03). However, at 30 minutes, 6.66% (n=4) of subjects in Group II had PONV compared to no subject in Group I (p=0.17). At 6 hours, PONV incidence was similar in both the groups with 20% (n=12) subjects each with p=1.000. At 2 and 12 hours, PONV incidence was higher in Group I where saline was used Conclusion: The study concludes that 5% dextrose administration perioperatively decreases the PONV incidence and antiemetics consumption in subjects undergoing laparoscopic hysterectomy surgery under general anesthesia

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