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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Macf-1 Rs2296172 Variant as Type 2 Diabetes Candidate Gene for Bhargava Population


    Dr. Babu Lal Meena, Dr. Subhash Chandra, Dr. Piyush Soni
    JCDR. 2023: 209-211

    Abstract

    Epidemiological transitions in India in the 21st century have led to non-communicable diseases becoming a major public health problem of growing magnitude. Aim: To establish MACF-1 Gene variant rs2296172 as a candidate gene for type 2 diabetes mellitus in Bhargava community. Methods: A community based cross sectional study conducted 68 previously diagnosed type 2 diabetic of Bhargava community and 60 non diabetic from general population receiving in the Diabetic Care and Research Center, Department of Medicine, S.P. Medical College attached to P.B.M. Associated Group of Hospitals, Bikaner. A camp was organized at Bhargava dera, KEM road, Bikaner for Bhargava community for sample collection. Results: In the population group, the frequency of risk allele (G) was found to be considerably higher in cases (0.235) as compared to that of controls (0.10). The variant was observed to be significantly associated with T2D with OR = 2.76 at 95% CI. Conclusion: our study show MACF-1 rs2296172 variant as an ideal type 2 Diabetes Mellites candidate gene for Bhargava population

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    Volume 14 Issue 9

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