Abstract

Elevated lipid levels during late pregnancy are associated with complications and adverse outcome for both mother and newborn. However, it is inconclusive whether a disturbed lipid profile during early pregnancy has similar negative associations. Aim: To evaluate the association of altered lipid levels and development of adverse maternal and fetal outcomes. Materials and methods: This is a Cohort study conducted in the Department of Obstetrics and Gynecology, in a Tertiary Care Teaching Hospital, Central India. Women attending outpatient department (OPD), antenatal care (ANC) and in patient department (IPD) in our hospital during the period of study were included. History clinical examination and all relevant investigation were done. All data were calculated and analyzed statistically. Result: Mean age of pregnant women in the study group was 24.89 ± 3.12 years, whereas in the control group, it was 24.72 ± 3.76 years. The levels of total cholesterol, triglycerides (TG), low density lipoprotein (LDL) and VLDL were significantly high in women who developed gestational diabetes mellitus (GDM) and preeclampsia as compared to those who did not develop GDM and preeclampsia (p<0.001). The levels of total cholesterol, TG, LDL and VLDL in women who developed preterm labor were found to be significantly high in women who developed preterm labor (p<0.01) as compared to women who did not have PTL. Women who developed small for gestational age (SGA) had statistically significant high levels of total cholesterol, TG, LDL and VLDL (p<0.05). The levels of total cholesterol, TG, LDL, VLDL, in women who developed macrosomia were not statistically significant when the two groups were compared (p>0.05). Conclusion: It was seen that third trimester maternal dyslipidemia is associated with various maternal and fetal complications such as gestational diabetes mellitus, preeclampsia, IHCP, preterm labor and SGA babies.

Description

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