Abstract

Sepsis is an extremely common and a highly lethal condition. Sepsis is the foremost cause of deaths and critical illnesses world over. One of the most frequently involved systems in sepsis is the Endocrine system. The most common thyroid abnormality in sepsis is Euthyroid sick syndrome (ESS). Therefore, this study aimed to measure the levels of Thyroid hormone and assess their relationship with mortality in patients of sepsis. Material and Methods: This is a cross-sectional observational study conducted at ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi- Intensive Care Unit, Emergency and Medicine ward from the duration of 1st January 2021-31st May 2022 with the sample size of 100 diagnosed cases satisfying the inclusion-exclusion criteria admitted in Department of Medicine. The analysis was done with the use of Statistical Package for Social Sciences (SPSS) software, IBM manufacturer, Chicago, USA, version 25.0 with the p-value<0.05 was considered statistically significant. Results: Total of 100 patients, majority were females (58%) with the age-group of 51-60 years. The mean value of qSOFA of study subjects was 2.51 ± 0.54 with median (25th-75th percentile) of 2(2-3) and range 2-4. Most commonly, the source of sepsis was found to be UTI (27%) > LRTI (18%) > septicaemia (11%). Statistically significant association was found between thyroid profile and the outcome (p-value<0.5). Conclusion: Incidence of sepsis is more common in older age and female gender. Older age, high qSOFA score is associated with increased mortality in patients with sepsis. UTI > LRTI are the most common source of sepsis. Low free T3 levels is most common abnormality in patients with sepsis. (90% patients). There is a positive correlation between low TSH level and decreased survival in patients with sepsis. Hence, TSH may be used as a predictor of mortality.

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