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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    MiRnome Profiling of Breast Cancer Cells: Seeking a Reliable Biomarkers


    Hanaa H. Ahmed, Hussein Sabit, Hanan A. Soliman Ahmed O. El-Gendy
    JCDR. 2023: 994-1004

    Abstract

    Breast cancer (BC) is elevating global wide and causing risky neoplasia in women at young ages. Besides, it is the most known disease that causes fear in women as it affects their self-esteem and confidence. Aim: The current study aimed at establishing a prediction model for BC based on epigenetic and genetics readings. Material and Methods: In this study, we used MCF-7 breast cancer cells to recognize the role of 95 different types of microRNAs (miRNAs). Results: The results showed that among 95 different miRNAs profiled, 6 miRNAs were found to be up-regulated, and 26 miRNAs were found to be down-regulated. After analysis, there was a link between the development of BC and the 6 up-regulated miRNAs. Conclusion: To reach early BC diagnosis, the 6 up-regulated miRNAs can be used as a biomarker. Specifically, has-miR-23b-3p was overexpressed in MCF-7 breast cancer cells and can be considered as a potential biomarker. Notwithstanding, more investigations and further studies are required to support these findings.

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    Volume 14 Issue 2

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