Abstract

Treatment options for Candidiasis include polyenes, azoles, echinocandins, nucleoside analogues, and allylamines, but drug resistance is a growing problem. Some species, like C. krusei and C. glabrata, exhibit high resistance to fluconazole and azoles. Accurate identification of Candida species and their susceptibility patterns is crucial for effective treatment. Mutations in the ERG11 gene, responsible for lanosterol 14α-demethylase enzyme production, lead to azole drug resistance, reducing their efficacy. This study focuses on identifying ERG11 gene mutations, offering prognostic and therapeutic significance in preventing drug resistance emergence.

Description

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