Abstract

Early detection through screening, effective investigative pathways and appropriate treatment have the ability to lessen breast cancer mortality rates. Thus the present study was undertaken to assess the role of morphometry on fine needle aspirates in accurate diagnosis of benign and malignant breast lesions. Materials and methods: 120 cases of Fine needle aspirates of breast lesions done at the Department of Pathology, Adichunchanagiri Institute of Medical sciences were take for nuclear morphometric study. Nuclear Morphometric parameters were measured using ProgresR capture pro 2.9.0.1 software. Data was expressed as mean values and percentage comparison between groups were done by unpaired t test and one way ANOVA test. Results: Nuclear parameters were significantly higher in malignant groups comparing benign ones (P value<.001) also between various cytodiagnostic categories (P value<.001). The Standard Deviation of these parameters is a quantitative measurement of nuclear pleomorphism, which was significantly lower in benign cases. Conclusion: Morphometric analysis of nuclear parameters can be used as an adjunct to FNAC for diagnosis of benign and malignant lesions, differentiating various cytodiagnostic categories and malignant grades of breast with precision and accuracy.

Description