Abstract

To determine the obstetric and neonatal outcome of pregnancy in women with epilepsy Materials and methods: This is an observational study conducted in was conducted in the Department of Obstetrics and Gynaecology in total number of 200 patients were studied out of which 50 pregnant women with epilepsy were taken as cases and 150 randomly selected pregnant women were taken as controls. The obstetric and neonatal outcome of pregnancy was compared in cases and controls. In cases, the seizure frequency in pregnancy, interval of last seizure before pregnancy and the AED used are compared. Results: According to the present study, maximum numbers of patients were in the age group 20-30 years in both the groups. The occurrence of oligohydramnios was 14% in cases and 12% in controls. IUGR was seen in 10% in cases and 12% in controls. The occurrence of preterm deliveries is 14% in cases and 4% in controls. The percentage of IUD was 6% in cases and 14% in controls. The rate of antepartum haemorrhage was 4% in cases, while it was 3.33% in controls. The subsequent development of preeclampsia was 12% in cases and 15% in controls. Mode of delivery was through the caesarean section in 47.92%, vaginal delivery in 52.08% and outlet forceps in 2.08% of the cases. In controls 20% delivered by LSCS, 74.67% had the vaginal delivery and 4.17% were delivered by outlet forceps. Induction of labour was done in 12.50% of cases and 12% of controls. The babies with birth weight <2.5kg was 31.37% in cases and 46% in controls. NICU admissions have been three for babies of women with epilepsy. Congenital anomalies in the newborn are seen in three cases on AED. In this study in cases on AED, seizures occurred during pregnancy in 16.66%cases and there were no seizures during pregnancy in 83.44% cases. In cases not on AED, seizures occurred in 45% cases, there were no seizures in 55% cases. In 15 (50%) cases Levetiracetam was used. In 2 (6.66%) cases carbamazepine was used. In 8 (26.68%) cases phenytoin was used. Combination of phenytoin and clobazam were used in 3 cases and Levetiracetam and clobazam were used in 2 cases. One maternal death in cases was found in the present study.

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