Abstract

Many new procedures, including pulp implantation, revascularization, and postnatal stem cell therapy, have been made possible by regenerative endodontics. These days, revascularization is successfully applied in clinical settings, giving dentists amazing outcomes. When administered in conjunction with a bone transplant or alone, platelet-rich fibrin (PRF) stimulates bone development and vascularization.This matrix encourages osteoblast migration, cell adhesion, and proliferation, which results in the production of bone. PRF is a packed fibrin complex made up of leukocytes, cytokines, and glycoproteins like thrombospondin. High success rates have been recorded when using PRF in surgical instances such sinus lift surgeries, extraction socket healing, and periapical abscess therapy. PRF is more cost-effective, simpler to make, and practical to employ in routine clinical procedures than platelet-rich plasma. Revascularization made it more difficult to induce a blood clot in the root canal space, a clinical victory. This further led to the use of platelet concentrates as an autologous scaffold for revascularization.PRF has a wide range of uses in regenerative endodontics, including revascularization of young permanent teeth with necrotic pulps and repair of iatrogenic pulpal floor perforations. It serves as a matrix where new tissue can grow.

Description