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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    PON1, Adiponectin and Visfatin: Predictors of CVD in women with PCOS


    Dr.Doddappa Mallappa Bannigida, Dr. Vijayashree Neeravari, Dr. Shivananda Nayak
    JCDR. 2023: 1831-1844

    Abstract

    One of the main causes of female infertility is polycystic ovarian syndrome (PCOS). Adipokines, such as visfatin and adiponectin, are released by adipose tissue. Visfatin mimics the effects of insulin. Visfatin mimics the actions of insulin by binding to the insulin receptor at a different site than insulin. Adiponectin is a Protein produced almost exclusively by adipocytes. Exerts strong insulin-sensitizing, anti-atherogenic, anti-inflammatory, and anti-diabetic effects. However, low levels are associated with obesity, IR, metabolic syndrome, T2DM, and CVD. Serum paraoxonase 1 (PON1) level is an antioxidant associated with HDL complex. Diminished activity of PON1 enzyme and increased levels of malondialdehyde (MDA) has been reported in variety of diseases involving oxidative stress. The CRP Elevated serum levels of CRP reflects chronic inflammation

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    Volume 14 Issue 9

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