Abstract

Preeclampsia (PE) is a hypertensive condition that occurs during pregnancy and accounts for 2% to 8% of complications related to pregnancy globally. The diagnosis of preeclampsia is made when the blood pressure exceeds 140/90 mmHg after 20 weeks of pregnancy, occurring on two separate occasions with a minimum time gap of 4 hours, or exceeds 160/100 mmHg within a short period of time. Several biomarkers have been identified for prediction and diagnosis of preeclampsia. One of these biomarkers is Placental induced growth factor (PlGF), a factor that promotes angiogenesis, which belongs to the vascular endothelial growth factor family. Significantly reduced serum levels of placental growth factor (PIGF) have been observed in women diagnosed with preeclampsia compared to normotensive pregnancies. This study was designed to answer the question whether the measurement of PIGF at third trimester might be a predictive factor for the appearance of preeclampsia.

Description