Abstract

Preformulation study of ketoprofen for transdermal therapeutic systems. METHODS: Identification of drug by organoleptic property, identification of drug by U.V. spectroscopy for determination of λ-max, identification of drug by fourier transform spectroscopy, solubility determination, partition coefficient, particle size, Melting Point, standard curve of Ketoprofen in methanol, standard curve of ketoprofen in phosphate buffer pH 7.4 RESULTS: The λ max of ketoprofen was found at 258 nm, which is comparatively same as given in I.P. This shows that the drug is pure. Results of qualitative solubility studies show that the ketoprofen is soluble in organic solvent and insoluble in water. So it is hydrophobic in nature. Quantitative solubility studies shown that ketoprofen is more soluble in methanol as compared to other solvents. The partition coefficient was found to be 3.47, which is suitable for transdermal drug delivery, the obtained value of partition coefficient of ketoprofen was more than 1 which showed that the ketoprofen is lipophilic in nature . The average particle size of ketoprofen was measured by microscopy method was found to be 2.2696 micrometer which is effective for better absorption through transdermal route. The melting point was observed at 90 0C, it shows the drug is crystalline & pure. The standard curve of ketoprofen was prepared in phosphate buffer 7.4 and in methanol, the r2 values was obtained 0.9995 and 0.9941 respectively, which shows linearity of absorbance between the range of 2-14 ug /ml. CONCLUSION: Oral therapy of Non-steroidal anti-inflammatory drugs is very effective, but the clinical use is often limited because of adverse effect such as irritation and ulceration of the gastrointestinal tract. Any drug for its permeation through skin should be potent, must be lipophilic as well as hydrophilic in nature, optimum partition coefficient etc, this prompted us to carryout the present study. The preformulation study for the ketoprofen was conducted. The preformulation study of ketoprofen showed satisfactorily results to select the drug for transdermal drug delivery system. Therefore, transdermal drug delivery has been considered to be an ideal route for administration of NSAIDs.

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