Abstract

A recently identified and potentially important addition in PCOS is low level of vitamin D. A number of studies have demonstrated association between vitamin D level and various PCOS symptoms including insulin resistance, infertility and hirsutism. (18-22) The main purpose of this study is to determine prevalence of abnormal vitamin D levels in PCOS women attending a hospital, compare these levels with non-PCOS group and to find out any relationship between BMI and insulin resistance in vitamin D deficiency. Materials and Methods: This observational study was carried out in the Department of Obstetrics and Gynaecology, B.R.Singh Hospital and Centre for Medical Education and Research, Eastern Railway, Howrah, West Bengal over a period of 15 months, among 90 consented women of age group 15-45 years who reported to the Gynaecology OPD. 60 were selected as cases and 30 as controls. Detailed history was recorded, general examination done, vitals recorded, anthropometric measurements were taken and hormonal and biochemical assays were carried out, apart from the ultrasound investigation. Data was collected, compiled and analysed using Epi Info (TM) 3.5.3.  2 test, Z-test and T-test were used wherever necessary. p-value< 0.05 was considered statistically significant. Result: Mean age of the PCOS patients was 27.13±5.59 years and majority (56.7%) were between 21-30 years. Mean age of control group was 28.36±5.69 years. Menstrual irregularities and hyperandrogenemia were more common among PCOS women. Menstrual cycle per year among women with PCOS had a mean of 5.63±0.78. Hirsutism and acne were also found more in PCOS women. 61.7% PCOS women had acne and the mean serum testosterone levels were 6.65±36.31ng/ml. BMI was seen to have a significant association with PCOS. Mean BMI of PCOS women was 26.89±4.19. Mean BMI of the control group was 23.07±2.57. All the patients with VitaminD deficiency had PCOS. The prevalence of Vitamin-D deficiency among the patients with PCOS was 11.7%. Mean level of Vitamin D in PCOS patients was significantly lower than that of patients without PCOS. (p<0.001). Among the PCOS women 11.7% were deficient in Vitamin D, 83.3% had insufficient level and 5% had optimal levels. The mean levels of vitamin D was 12.57±4.06 ng/ml with a median and range of 12.01ng/ml and 5.40- 24.30ng/ml respectively. Among the control group 80% had insufficient levels and 20% had optimal levels of vitamin D. They had a mean of 15.25±4.78 ng/ml and a range of 8.25- 25.40ng/ml. The risk of deficiency or insufficiency of Vitamin D was 4.75 times more among patients with PCOS as compared to patients without PCOS and the risk was significant [OR-4.75 (1.09, 20.57);p=0.025].

Description

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