Abstract

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and is classified as a carcinogenic infectious agent by the International Agency for Research on Cancer. However, only some HPV strains are oncogenic. The oncogenicity of the virus is primarily dependent on the continuous expression and activity of the viral proteins E6 and E7. HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73 and 82 are considered high-risk genotypes, Of the high-risk HPV types, HPV16 is the most frequently detected at the population level, and it is by far the predominant type causing invasive cervical cancer worldwide (~60%), followed by HPV18 (~15%) [23]. HPV serotypes 16 and 18 together cause up to 70% of invasive cervical cancer worldwide. Cervical cancer ranks as the 2nd leading cause of female cancer in India. This is the most frequently occurring type of cancer in women aged 15 to 44 years after breast cancer. Objective: To study the qualitative detection of Human papillomavirus (HPV) DNA in clinical samples and genotyping of 14 high-risk (HR-HPV).

Description