Abstract

The most prevalent endocrine disorder in developing countries is related to thyroid imbalance. Hypothyroidism is a common endocrine disorder with reduced production of thyroid hormones. It is a common disease with different frequency between countries. It occurs in 10% of women and 6% of men with age >65 years (Das et al, 2012)1 . However, the common occurrence of hypothyroidism was three times more in women than in men (12.4% versus 3.7%) in developing countries like Spain. Sex, geographical factors, age, ethnicity and iodine consumption are the determining factors for the occurrence of thyroid problems (Das et al, 2012)1 . AIM :To find the prevalence of Vitamin-B12 deficiency in cases of hypothyroid patients. Methodology:The present study was conducted on patients presenting to the Department of General Medicine OPD and IPD admitted patients with diagnosed Hypothyroidism at Pacific Medical College & Hospital, Pacific Medical University, Bhelo Ka Bedla, Pratap pura, Udaipur. Study population included 100 diagnosed hypothyroid patients. Smokers patients with hypertensiom, cardiac, hepatic and renal disorders were excluded from the study. Subjects on vitamin B12 supplements and on medication affecting thyroid also excluded from the study. Following parameter are evaluated:- Body Mass Index Following investigations were performed for the study outcome:- CBC with Peripheral Blood Smear Vitamin B12 FBS (fasting blood sugar) T3, T4, TSH Lipid profile TPO antibodies Result:The prevalence of Vitamin B12 deficiency among hypothyroid patients was found to be 38%. The prevalence of Vitamin B12 deficiency among hypothyroid patients was highest among patients of age 20-30 years (47.7%) and was lowest among patients of age >40 (18.8%) years. The mean age of patients of with deficiency and without deficiency was 32.05±1.64 and 40.03±14.23 years respectively. The prevalence of Vitamin B12 deficiency among hypothyroid patients was higher among unemployed patients (39.2%) than employed (36.7%). However, there was no significant (p>0.05) association of prevalence of Vitamin B12 deficiency among hypothyroid patients with occupation. Conclusion:It is concluded that patients with hypothyroidism have a higher prevalence (38%) of vitamin B12 deficiency. Age, BMI and Addiction habit were significantly associated with prevalence of vitamin B12 deficiency.

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