Abstract

To assess prevalence of vitamin B12 deficiency in patients with thyroid disorders. Material and Methods: A total of 105 patients, comprising both genders, were enrolled in the study due to thyroid disease. The assessment involved measuring thyroid-stimulating hormone, free T4, free T3,vitamin B12, and thyroid antibodies (ab). Gastrin levels were determined through radioimmunoassay, while vitamin B12 levels were analyzed using the Access chemiluminescence immunoassay. Results: Out of 105 patients, males were 45 (42.9%) and females were 60 (57.1%). Out of 105 patients, 62 (59.4%) had Hashimoto thyroiditis, 40 (38.7%) had Grave’s disease and 3 (2.8%) had other diseases. The difference was significant (P< 0.05). Out of 62 cases of Hashimoto thyroiditis, 35 had normal and 27 had low vitamin B12 level. Out of 40 cases of Grave’s disease, 33 had normal and 7 had low vitamin B12 level. Out of 3 cases of other thyroid diseases, 2 had normal and 1 had low vitamin B12 level. The difference was non- significant (P> 0.05). Out of 24 cases of normal gastrin, males were 8 and females were 16. Out of 11cases of elevated gastrin level, 4 were males and 7 were females. The mean Vit B12 level in cases of normal gastrin level was 107 pmol/L and in cases of elevated gastrin level was 95 pmol/L. Positive PCA was seen in 2 and 9 patients having normal and elevated gastrin level respectively. Conclusion: There was high prevalence of vitamin B12 deficiency patients with thyroid diseases. Therefore, routine screening and assessment of vitamin B12 status can help detect deficiencies early and enable appropriate supplementation if needed

Description

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