Abstract

Basic gynaecological endocrinology has been of paramount significance in the investigative approach in cases of menstrual dysfunction with infertility. Objective: Aim of the study is serum prolactin assays in cases of infertile patients with menstrual dysfunction. Material and Methods: A prospective case control study conducted over a period of 1year. Reproductive age patients of 20to 40yrs were slected and categorized into two groups. Control Group: Comprised of 50 fertile women with normal menstrual cycles and fertility. Study Group: Comprised of 150 infertilile women (primary or secondary) with menstrual dysfunctions. Detailed obstetrics history with relevant laboratory, radiological investigations including serum prolactin level was done. Results: incidence of hyperprolactinaemia in our study was 24.6%. Incidence of hyperprolactinamia in different menstrual disorders in oligomenorrhoea was 27.27%. In secondary amenorrhoea 30.2%. Primary amenorrhoea 5.5%, polycystic ovarian disease33.3%, irregular menstruation (9.09%), regular anovulatory cycles (25%) regular ovulatory cycles (40%). In our study in hyperprolactinemic patients, majority of patients presented with oligomenorrhoe (48.7%) as menstrual abnormality followed by secondary amenorrhoea (35.1%). In our study the mean serum prolactin level in patients with secondary amenorrhoea (111.42ng/ml ) was significantly higher than in patients with oligomenorrhoea (69.3ng/ml) incidence of primary infertility in hyperprolactinemia cases.was 75.67%and secondary infertility (27.07%).The test of proportion showed high significant difference between the two(p<0.01). In our study, incidence of hyperprolactinemia in patients with galactorrhoea was( 66.6%) high significant difference(p<0.01)was observed between serum prolactin levels of cases with galactorrhoea and without galactorrhoea. galactorrhoea was not a constant feature only 13.5%of hyperprolactinaemic patients had demonstrable galactorrhoea. Conclusion: Hyperprolactinemia is quite an important cause of infertility and menstrual dysfunction, hence serum prolactin estimation is mandatory for diagnosis.

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