Abstract
The study's objectives were to assess the prosthetic heart valve thrombosis's clinical presentation, underlying causes and diagnostic indicators, treatment approaches, and complications, as well as to assess the effectiveness, outcomes, and side effects of thrombolytic therapy during the hospital stay. Methods: This study is conducted in the Department of Cardiology, Kurnool Medical College, Kurnool, Andhra Pradesh, India, for January 2020 to January 2022, with 30 sample size. Results: Majority of the patients were in 31-40 years, most common patients were male (77%), females patients were less common (23%). Most common symptom was breathlessness, mitral valve involvement was most common (76.7%), followed by aortic (20%) least common both valves were involved (3.3%). In this study most common patients were poor adherence of either warfarin or acitrom drugs (90%), good drug compliance around (10%) of patients. In present study INR value <2.5 in 90% of patients, INR value >2.5 in 10% of patients. Most of the patients having low INR, less number of patients having INR more than 3. INR Vs NYHA class by using fisher test P value was significant. Conclusion: Thrombolysis was done in all patients with STK in 63.3%, TNK was used in 36.8%. Success in 93.3%, failure 6.6%. In present study complications during thrombolysis embolism in 20% cases, bleeding in 10% of cases, death only 3.3% of cases. In present study success following thrombolysis (93.3%), failure of thrombolysis patients were (6.7%).