Abstract

- Thrombophilia refers to a series of acquired and inherited conditions that confer an increased risk for thrombus formation. Protein C and S deficiency are hereditary conditions associated with thrombophilia..(1) MI (Myocardial Infarction) with non-obstructive coronary arteries (MINOCA) is being increasingly recognized with the frequent use of angiography. To diagnose MINOCA, it is very important to identify the underlying different potential mechanisms like thrombophilia that may require different managements, especially in young individuals.(2) Objectives- 1)To estimate the proportion of young MI patients with low protein S and protein C profile with their first episode of MI 2)To determine the clinical outcome of these patients during the period of hospitalization. Methodology-After identifying the study population based on the inclusion criteria, study participants were selected. Also,details of echocardiography, angiographic results if any,ECG and clinical history were noted in each case during their presentation. Patients were followed up for 3 weeks until next review in OPD, and blood samples were then obtained in citrated tubes. The platelet poor plasma obtained from these samples were stored at -70 degree Celsius, and later performed coagulation screening tests, Protein C and S assay. Results- Out of 112 cases studied, 6.2% (7 cases) were detected with protein C deficiency and 4.4 % (5 cases) with protein S deficiency,and 2 cases had a combined protein C and S deficiency. Conclusion- Protein C/S deficiency were detected in a minor proportion of cases with coronary- arterial thrombosis in the young. Tests for protein C/S could be included in the workup for MINOCA in young individuals

Description

.