Abstract

Post operative nausea and vomiting (PONV) is a common complaint, with an incidence of up to 80% in high risk patients. The present study was conducted to compare ramosetron with ondansetron for the prevention of post-operative nausea and vomiting in high-risk patients. Materials & Methods: 100 adults undergoing surgeries of both genders were divided into 2 groups of 50 each. Group I received ramosetron 0.3 mg and group II received ondansetron 8 mg, 30 min before the end of surgery. The incidence of PONV, severity of nausea and need for rescue antiemetic were recorded over the next 24 hours. Results: Group I had 26 males and 24 females and group II had 25 males and 25 females. Nausea was seen in 36% and 39%, retching in 9% and 16%, emesis in 13% and 10% and rescue anti- emetic in 24% and 30% in group I and II respectively. The difference was significant (P< 0.05). Nausea was none in 45% in group I and 70% in group II, mild in 30% in group I and 20% in group II and normal in 25 %in group I and 10% in group II. The difference was significant (P< 0.05). Conclusion: Both Ramosetron 0.3 mg and ondansetron 8 mg were equally effective in reducing the incidence of PONV in high- risk patients.

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