ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    RELATION BETWEEN BIOCHEMICAL PROFILE OF METABOLIC SYNDROME AND CHRONIC KIDNEY DISEASE


    Dr Jaya Varagani , Dr Vijaya Lokary, Dr Baburao Eruku Dr Christy Pradeep
    JCDR. 2019: 121-135

    Abstract

    The current study provides new and important information regarding the relationship between the metabolic syndrome and risk of CKD in a representative sample of adult population and suggests that prevention and treatment of the metabolic syndrome should be an important priority for reducing the prevalence of CKD and its associated disease burden in adult population. Aims: To study the relation between Biochemical Profile of Metabolic syndrome and Chronic Kidney Disease. Materials and methods: Hospital based observational study conducted in the department of Biochemistry, among the patients who are eligible for metabolic syndrome criteria. Any of the three parameters meeting the inclusion criteria in a patient will be tested for serum creatinine and GFR <60ml/min/1.73m2 according to MDRD formula. Results: In our study, prevalence of CKD in Metabolic syndrome is 41.2%, that is very significant, approximately one third of study patients with Metabolic syndrome leading to Chronic Kidney Disease. Diabetes mellitus found have significant association with CKD with a p value of 0.006, similarly dyslipidemia had some impact on patients leading to CKD as the TG and HDL as the p values of them are in borderline significant. And finally hypertension found to have a significant association with CKD with a p value of 0.04. Incidentally 22% of the study patients are having Acute Kidney Injury because of various etiologies. Conclusion: The present study identified a strong, positive, and significant relationship between the metabolic syndrome and risk of CKD in the general adult population. The risk of CKD increased progressively with a higher number of components of the metabolic syndrome. These relationships were independent of potential risk factors for CKD including age, DM, HTN, triglycerides and BMI.

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    Volume & Issue

    Volume 10 Issue 3

    Keywords