Abstract

Prostate cancer (PCa) is one of the most common type of cancer among men. Many prostate cancers grow slowly and are confined to the prostate gland, where they may not cause serious harm. Almost all prostate cancers are adenocarcinomas. Androgen-deprivation therapy can cause adverse cardiovascular or metabolic effects such as decreased insulin sensitivity, increased levels of blood cholesterol and triglycerides, decreased lean mass, and increased fat mass. Adipocytes and other cells of adipose tissue secrete adipokines and cytokines including leptin, adiponectin, resistin, visfatin, omentin, and IL-6. It was found that PCa cells alter adipocytokines secretion from periprostatic adipose tissue, thus interactions between adipocytes, stromal and cancer cells are mutual

Description