Abstract

Hypertension and dyslipidemia are prevalent comorbid conditions that significantly increase the risk of cardiovascular diseases. Understanding the interplay between lipid profiles and hypertension can aid in optimizing treatment strategies to improve clinical outcomes. Objectives This study aims to evaluate the lipid profiles of hypertensive patients at BMIMS Pawapuri and investigate the correlation between lipid abnormalities and hypertension control. It also assesses the impact of combination therapy with antihypertensive and lipid-lowering drugs on lipid parameters. Methods A hospital-based retrospective descriptive study was conducted, involving 50 hypertensive patients treated at BMIMS Pawapuri from March 2023 to February 2024. Data on demographic characteristics, medical and medication history, blood pressure, and lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were analyzed. Statistical analyses included descriptive statistics, correlation analysis, and tests of significance for comparing means across different treatment groups. Results The mean lipid values were as follows: total cholesterol 205 mg/dL, LDL cholesterol 130 mg/dL, HDL cholesterol 40 mg/dL, and triglycerides 150 mg/dL. Approximately 46% of patients had elevated LDL levels, and 54% exhibited reduced HDL levels. Statistically significant correlations were found between uncontrolled hypertension and higher LDL levels (r = 0.34, p < 0.05), as well as controlled hypertension and higher HDL levels (r = -0.29, p < 0.05). Patients on combination therapy showed significantly improved lipid profiles compared to those on antihypertensive therapy alone. Conclusion The study highlights a significant prevalence of dyslipidemia among hypertensive patients and supports the efficacy of combined antihypertensive and lipid-lowering therapy in improving lipid profiles. These findings advocate for integrated management approaches to address both hypertension and dyslipidemia, potentially reducing cardiovascular risk and enhancing patient health outcomes.

Description