Abstract

Large epidemiologic studies have shown that hyperuricemia is associated with an increased incidence of coronary artery disease. Aims: This study aims to explore the relationship between serum uric acid level and Gensini score, which in turn reflects the severity of coronary artery disease Methods: A retrospective cohort study was conducted in patients presenting with ACS at tertiary care centre, Bagalkot. Hyperuricemia was defined as serum uric acid level > 6 mg/dl. Severity of coronary artery disease was assessed on the basis of Gensini score. Number of diseased vessels, critical lesions and total occlusions on coronary angiogram was taken into consideration Results: Mean uric acid levels of normouricemic and hyperuricemic groups were 4.7±1.1 and 7.53 ± 1.32 respectively with p value of 0.001. Mean Gensini score of normouricemic group was (20.56 ± 13.66) while hyperuricemic group was (35.53 ± 17.84). Chi square, independent t test was applied to compare the Gensini score of two groups and it resulted in p valve of 0.001 which is statistically significant. Spearman correlation revealed a positive correlation between serum uric acid level and Gensini score which was found to be statistically. Significant difference was observed in total occlusions (p=0.001) and left main coronary artery stenosis s (p=0.001) which were higher in the hyperuricemic group compared to normouricemic group.

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