Abstract

It has been observed that the changes in the systemic arterial circulation, portal hypertension, commencement of vasoconstrictors and inhibition of vasodilatory factors acting on the renal circulation were the factors which led to development of renal impairment in CLD and cirrhosis. Material and Methods: This study was done in Department of Biochemistry in Prasad Institute of Medical sciences, Banthra, Lucknow, U.P. Total 43 cases were included in this study. The duration of study was over a period of two year. Results: Out of the 43 patients of cirrhosis, the cause of liver disease was attributed to alcoholism in 21 patients. 6 patients were found to be positive for Hepatitis B surface antigen. Out of the 43 patients, renal function was assessed by serum creatinine, creatinine clearance from timed urine collection [(UxV)/P] and creatinine clearance by Cockcroft Gault formula (CGF). Conclusion: It can be concluded that estimation of Serum creatinine alone has not been found to be a reliable marker to assess renal dysfunction in CLD.

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