Abstract

Background: Hypothyroidism patients are more prone to get kidney disorders due to thyroid dysfunction. We aimed to determine the supplementation of thyroxine can reverse renal dysfunction in patients with hypothyroidism. Methods: This observational study, included A total 60 patients who were presented with hypothyroidism (30 were hypothyroidism with AKI and 30 were hypothyroidism with CKD). We estimated RFT, CPK, eGFR, T4, TSH and Urinary Proteins levels were measured before and after supplementation of thyroxine. Results: The age, urea, creatinine and urinary protein does not shown any significance between baseline and after supplementation of thyroxine in patients with hypothyroidism and AKI, CKD respectively P value is >0.05. The T4, TSH and eGFR shown a significant between baseline and after supplementation of thyroxine in patients with hypothyroidism and AKI respectively P value is 0.001**. The serum urea, creatinine, CPK, T4, TSH, eGFR and urinary protein shown a significant between baseline and after supplementation of thyroxine in patients with hypothyroidism and CKD, respectively P value is 0.001**. Conclusion: Based on study findings, the renal dysfunction occurs in moderate to severe hypothyroidism and it is reversible upon adequate thyroxine supplementation. Thyroid function testing should form an integral part of the first line blood investigations for patients with impaired renal function. Hypothyroidism should be considered as a cause for sudden deterioration in hitherto stable CKD.

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