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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Role of Prostaglandin (PGE1) in Patients with Nonhealing Ulcers due to Thromboangitis Obliterans (Buergers disease)


    Dr Gaurav Singal, Dr Dipesh Goel , Dr Harshita Mittal
    JCDR. 2023: 1771-1777

    Abstract

    PGE1 is effective in treatment of Buergers disease. It reduces pain in limbs, improves wound healing and prevents amputation. PGE1 is a form of prostaglandin which causes peripheral vasodilatation, improvement of microcirculation, anti-inflammatory immune modulation and inhibition of platelet aggregation. Aim To determine the role of PGE1 in Buergers disease (BD). Methods A Prospective cohort study was undertaken from April 2022 to March 2023 at a Medical college hospital. 72 patients were included in the study. Improvement in wound size and side effects of PGE1 were studied. Results The mean of improvement in wound size expressed in percentages at 4 weeks and 8 weeks were 45.7±2.8 % and 85.2±4.3% respectively. The mean of ankle brachial pressure index (ABPI) at 0 weeks was 0.5 ±0.37 and at 12 weeks was 0.82±0.03 respectively. Conclusions PGE1 is very effective in treatment of Buergers Disease with minimal side effects.

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    Volume 14 Issue 8

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