Abstract

A 33 KDa serine hydrolase enzyme known as monoacylglycerol lipase is associated with a number of physiological processes in people, including pain, inflammation, and neurodegenerative diseases. The enzyme has been discovered to be associated with the endocannabinoid lipid signalling network system and has been found to be present in both the central and peripheral nervous systems. Enzyme support the growth of cancer and tumour cells by acting as a source of free fatty acids. It has been noted that the enzyme's activity is elevated in dividing and expanding cells in a number of cancer types. The signalling molecules phosphotidic acid, lysophosphatidic acid, sphingosine phosphate, and prostaglandin E2 are found to be free fatty acid-derived and have been linked to the proliferation, migration, and survival of cancer cells. They also rise as a result of enzyme activity. In the current work, we have carried out the identification task and screening investigation for the newly developed carbamate derivatives as anti-cancer moieties using docking and other computational tools.

Description

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