Abstract

Hospital based prospective cross sectional study conducted at a tertiary care center on Estimation of Serial QT on day of admission, day 3rd, day 5th and day 7th in ECG of patients admitted in critical care at tertiary care centre. Materials and Methods: An observational, cross-sectional with prospectively collected data, From January 2021-April 2022 in adult patients admitted to medical (M), surgical (S), and emergency (E) ICUs, and HDU in a Mahatma Gandhi Medical Hospital, Jaipur. All study patients signed an Informed Consent Form. During the study period, all patients of both genders, over 18 years-old, admitted to the ICU were invited to the study. Result: In current study, the mean QTc value more than 500ms were found in patients with CAD with ischemic disease, CKD, Pneumonia with Sepsis, HF, TB with ATT, Seizure with metabolic abnormality, and patients taking Trimethoprim-Sulfamethoxazole drug on day of admission, 3rd day, 5th day and 7th day. Conclusion: The prevalence of prolonged QTc interval is high in Indian emergency medical patients. There was no difference in hospital mortality though on subgroup analysis, patients with markedly prolonged QTc interval had significantly more episodes of in hospital ventricular tachycardia and hospital mortality. A variety of factors including certain comorbidities, biochemical abnormalities and drugs were associated with QTc prolongation. Based on findings of index study, it would be prudent to closely monitor QTc interval, especially in patients with certain comorbidities and biochemical abnormalities, avoid medications associated with QTc prolongation

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