Abstract

Organophosphorus compounds have assumed considerable importance in most parts of the world. Though these compounds were discovered a century ago, even now they are the widely used insecticides all over the world. Aims and objectives of these study was to assess serum creatine phosphokinase level in OP poisoning. Material and Methods: The present study was conducted on a sample of 50 patients who were admitted to Department of General Medicine, SVS Medical College and Hospital Yenugonda, Mahbubnagar, Telangana, 509001, India, exhibiting a documented history and clinical manifestations consistent with organophosphate poisoning. Study was conducted between the April 2023 to September 2023. Results: Organophosphorus chemicals are often employed substances for self-harm due to their widespread accessibility. The primary determinants of death encompass the specific toxic chemical employed, the extent of poisoning, the timing of treatment initiation, and the availability of intensive care resources. Although acetylcholinesterase has several advantages, it can result in an overstimulation of muscarinic and nicotinic receptors. The clinical presentation of cholinergic crisis typically manifests rapidly, serving as the primary basis for clinical diagnosis. Confirmation of this diagnosis is typically achieved by the patient's medical history and the use of demonstrative monitoring. Conclusion: The study observed that following treatment, levels of creatine phosphokinase returned to baseline levels, accompanied by a subsequent enhancement in the patient's clinical state. The optimization of the mean dose and duration of Atropine and pralidoxime treatment is a topic of interest, as it has been seen that greater doses are required in severe instances.

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