Abstract

Non-invasive ventilation (NIV) reduces the rate of endotracheal intubation and overall mortality in severe acute exacerbation of COPD (AECOPD) with respiratory failure. However, poor patient selection and ineffective NIV administration lead to higher mortality. We aimed to identify factors that predict the outcome of NIV in AECOPD. METHODOLOGY: We have conducted prospective observational study in the Department of Pulmonary Medicine Government Chest diseases and TB hospital, Hanmakonda, Telangana. between November 2020 to July 2022. Patients who were admitted with AECOPD with increased work of breathing and PaCO2 >45mm Hg were included in this study. COPD was diagnosed with history, clinical examination, chest X-ray PA View and previous spirometry. Blood gas analysis was done to assess PaCO2, PaO2 and PH before and after NIV administration after clinical improvement. RESULTS: Total 40 patients were included in this study of which 12.5% were female and 87.5% were male patients. Out of 40 patients, 37 patients improved with NIV treatment and remaining 3 failed to improve. Duration of NIV treatment depends upon following factors like sputum consistency, current history smoking, respiratory rate at the time of admission, presence of comorbidities (corpulmonale,diabetes) high PaCO2 levels and low PH levels

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