Abstract

Osteoarthritis [OA] is a degenerative joint disorder of synovial joints. This study was done to evaluate the efficacy of injection of platelet rich plasma versus high molecular weight viscous supplementation in osteoarthritis knee. Materials & Methods: Thirty patients were chosen and randomly divided into two groups of 15 each. Patients with same K L grade in both knees were chosen for study. In group A, patients were given platelet rich plasma in right knee and high molecular weight viscous supplement in left knee. In group B, patients were given high molecular weight viscous supplement in right knee and platelet rich plasma in left knee. Comparison was done between the PRP receiving group and Hyaluronic acid receiving group. Comparison was done on the basis of reduction in pain and discomfort as asessed by visual analogue scale and consumption of analgesic as oral paracetamol consumption by patients . No of paracetamol tablets consumed by patients in a period of 30 days prior to visit at 1 , 3 and 6 months of follow-up were noted . Results: Age group <40 years comprised of 3 (10%). Age group 41-50 years had 9 (30%). Age group 51-60 years had 11 (36.7%) patients. Age group >60 years had 7 (23.30%) patients. The mean±SD age was 50.2± 7.26 years. Out of 30 patients, males were 21 (70%) and females were 9 (30%). The mean± SD VAS was 75.46±8.1 in PRP patients and 40.53±5.6 in HA patients at 1 month. The difference was significant (P< 0.05). The mean± SD VAS was 54.24±6.2 in PRP patients and 64.78±9.4 in HA patients at 3 months. The mean± SD VAS was 43.93±4.6 in PRP patients and 70.61±8.2 in HA patients at 6 months. The mean paracetamol consumption at 1 month in PRP patients was 13.5±4.1 and in HA patients was 7.3± 1.2. The difference was significant (P< 0.05). The mean paracetamol consumption at 3 months in PRP patients was 9.2±2.8 and in HA patients was 12.4± 4.6. The mean paracetamol consumption at 6 months in PRP patients was 5.67±1.3 and in HA patients was 15.4± 3.8. The difference was significant (P< 0.05). Conclusion: The first line of treatment for knee osteoarthritis should be platelet rich plasma (PRP) injections. PRP may be combined with viscous supplement (HA) injection as a worthwhile option for effective treatment of knee osteoarthritis.

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