Abstract

Antibiotics play an important role in the post-operative management of surgical patients due to high incidence of surgical site infection [SSI]. SSIs impact both the patient and health care system through increased mortality and morbidity, prolonged hospital admission and additional treatment cost. This study aims to prove that single-dose antibiotic prophylaxis is as effective as conventional antibiotic therapy in reducing SSIs in clean and clean-contaminated surgeries Material and Methods: A total of 140 patients were divided into two groups with 70 patients in each group. All patients planned for surgery were given Inj. Ceftriaxone 1gm+sulbactum 500mg ,30 min before surgery. In the control group, the patients were given an additional injection of ceftriaxone 1g + Sulbactam 500mg twice a day for the first 3 postoperative days followed by oral cefixime 200mg twice a day for the next 5 days. The outcome in terms of post-op fever, surgical site infection and other related complications were studied. Results: In This study, 47.8% of patients were female, and 52.1% of patients were male. In Group-A, patients having post-operative seroma, fever, SSI and leucocytosis were 7.14%, 4.2%,2.8% and 2.8% respectively. In Group B, patients having post-operative seroma, fever, SSI and leucocytosis were 1.4%, 7.14%,1.4% and 2.8% respectively. There is no statistically significant difference between the two groups regarding postoperative seroma, fever, SSI and leucocytosis. Conclusion: Prophylactic single-dose antibiotic is effective in prevention of surgical site infection and is costefficient for patients undergoing clean and clean-contaminated surgeries

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