Abstract

Background: Pediatric cardiac disorders present significant therapeutic challenges. Stem cell therapies have emerged as a potential regenerative solution, offering prospects for substantial cardiac repair and functional improvement in children. Methods: This multicenter, randomized controlled trial evaluated the efficacy and safety of stem cell therapies for cardiac repair in pediatric patients. A total of 200 participants were randomized to receive either stem cell therapy or conventional medical management. The primary outcomes measured were successful cardiac repair, improvement in cardiac function, and the safety profile, including the incidence of adverse events over a follow-up period of one year. Results: The treatment group showed a significantly higher rate of successful cardiac repair (70% vs. 50%, p=0.001) and improvement in cardiac function as evidenced by enhanced ejection fraction and reduced heart size on imaging.

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