Abstract

Dengue is a mosquito-borne viral infection that causes significant morbidity in endemic regions. Various patterns of renal involvement have been observed in patients with dengue that include increase in serum creatinine level, AKI, acute tubular necrosis, hemolytic uremic syndrome, proteinuria, glomerulopathy, and nephrotic syndrome. Present study was aimed to study renal complications in dengue positive patients at a tertiary hospital. Material and Methods: Present study was prospective, comparative study, conducted in patients of age > 18 years, either gender, diagnosed with dengue viral fever, having confirmed diagnosis of Dengue Fever with positive IgM and/or NS1 Ag, had acute kidney injury on admission or during treatment. Results: Incidence of AKI in present study was 16.01 %. According to severity of dengue disease among total dengue cases, 69.79 %, 26.89 % & 3.32 % patients with dengue fever, dengue hemorrhagic fever & dengue shock syndrome. In patients with AKI incidence of dengue fever, dengue hemorrhagic fever & dengue shock syndrome was 9.09%, 25.84 %, 81.82 %. Among AKI cases, majority were from > 60 years age (47.17 %), were male (60.38 % %). Male to female ratio with AKI in present study was 1.52:1. Overall, 50.94 %, 28.3 % & 20.75 % incidence noted in AKI stage I,II & III respectively. Stage I AKI was common in dengue fever (76.19 %) & in dengue hemorrhagic fever (47.83 %), while stage 3 AKI was common in dengue shock syndrome (66.67 %). Majority patients had complete recovery (69.81 %), while 5 patients (9.43 %) had partial recovery. 17 patients (32.08 %) required Renal replacement therapy. Mortality was noted in 11 patients (20.75 %). Conclusion: Acute kidney injury in patients of dengue was noted in male gender, advanced age (> 60 years) & dengue shock syndrome.

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