Abstract

Background: Metabolic syndrome is an accretion of numerous disorders, which composed advance the risk of an individual emerging atherosclerotic cardiovascular disease, insulin resistance, and diabetes mellitus, and vascular and neurological complications. MetS has been associated with a pro-inflammatory state branded by raised plasma concentrations of several markers of inflammation. Present study was aimed to study association between high sensitivity C reactive protein (CRP) and metabolic syndrome. Material and Methods: Present study was cross-sectional observational study, conducted in patients diagnosed with Metabolic Syndrome according to the NCEP ATP III criteria. Serum hs-CRP levels were to be determined by immuno-turbidometric assay using with dedicated reagents. Results: In present study, among 78 subjects mean age of the study population was 49.24 ± 10.45 years. 70(92.1%) of study subjects were females and 6(7.9%) were males. Among 76 study subjects, 48(63.2%) of subjects had Diabetes Mellitus and 67(88.2%) had Hypertension. There is positive correlation between waist circumference (r value= 0.43, p-0.034), BMI (r value= .74, p 0.02), FBS (r value= .36, p 0.04), SBP (r value= .34, p 0.045) and DBP (r value=.47, p value-.047) and hs-CRP. This showed that patients with elevated hs-CRP has higher waist circumference, high Body Mass Index, high FBS, high SBP and DBP (HTN). There is a negative correlation between hs-CRP and HDL, showing that an elevated hs-CRP is associated with lower values of HDL (r value= -0.56, p-0.03). This shows that there is an inverse relationship between HDL an hs-CRP showing that when hs-CRP increases, HDL decreases. 50(71.4%) of females had hs-CRP of high-risk category, 68.8% of Hypertensives had hs-CRP of high-risk category, 74.6% of Diabetics had hs-CRP of high risk category. These association were statistically significant. Conclusion: There was positive correlation between waist circumference, BMI, FBS, SBP and DBP (components of metabolic syndrome) and hs-CRP.

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