Abstract

Thyroid dysfunction is known problem in Indian population, vary from hypothyroidism to hyperthyroidism. Subclinical hypothyroidism is defined biochemically as a normal serum free thyroxine (T4) concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. Our study aimed to study the association between subclinical hypothyroidism on diastolic function of the heart. Material and Methods: Present study was single-center, case control study, conducted patients more than 18 years age, had elevated TSH level higher than the upper limit range 4mU/L but below 10mU/l and normal levels of T3 and T4 without any clinical features of hypothyroidism. Present study involved 31 Subclinical hypothyroid and 31 normal individuals with normal thyroid profile. Results: There was a statistically significant difference found between cases and controls with respect to Total Cholesterol. There was a statistically significant difference found between cases and controls with respect to Peak E-early mitral flow rate, Peak A-late mitral flow rate, E/A ratio, E/E’-early mitral flow velocity/mitral valve tissue velocity. There was no statistically significant difference found between cases and controls with respect to DT-deceleration time. Among those who have sub clinical hypothyroidism 45.2% have abnormal peak E value when compared to 3.2% among controls and this was found to be statistically significant. Similirly 25% of the cases were found to have abnormal peak and 3.2% of the cases were found to be statistically significant. E/A ratio was significant in cases when compared to controls with 29% being abnormal in cases and 3.2% in the controls. DT and E/E' was not significant. Conclusion: Subclinical hypothyroidism is significantly associated with symptomatic with NYHA GRADE 2 breathlessness as well as left ventricular diastolic Dysfunction. Evaluation by 2D echocardiography in patients with subclinical hypothyroidism helps for early detection, treatment & follow-up.

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