Abstract

Cancer is the second largest killer disease. Cancer Of the breast is common in women in developed countries and more than 40% of all breast cancer cases found in developing countries. The present study was done for the early detection of carcinoma. Methodology: The present study was conducted in the Department of Biochemistry, Rangaraya Medical College, Kakinada, and Andhra Pradesh, India. The present study was undertaken to determine biochemical changes in60carcinomabreastcases.60casesweredividedinto2groups-a. Premenopausal 30 cases, and b. Post-menopausal 30 cases, who were newly diagnosed and untreated. These values are compared with40 healthy controls. All of these subjects were taken from surgery department, Government General Hospital, Kakinada. R.B.S., Total Proteins, Albumin, A/G ratio, lactate dehydrogenase, gamma glutamyl transferase and liver enzymes (T. Bilirubin, SGOT, SGPT, ALP) were estimated among cases and controls. Results:. Mean values of LDH, GGT, PROTEINS, ALP were significantly increased in all the cases when compared with controls. Conclusion: These findings suggest that the estimation of less specific biomarkers like LDH, GGT and ALP can be used as routine tests in all suspected carcinoma breast patients because these can be easily assayed, approached for general population, less expensive and can detect metastasis also

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