Abstract

Diabetes Mellitus is a metabolic disorder and associated with number of disorders including bone, kidney, liver, nerves, had and blood vessels dysfunction. C- reactive protein (CRP) is a sensitive physiological biomarker of subclinical inflammation associated with hyperglycemia. The objective of the present study was to establish the relationship between CRP with blood sugar and Alkaline Phosphatase (ALP) in serum of Diabetes Mellitus (DM2). Materials and methods: This study was a hospital based cross sectional study conducted in the Department of Biochemistry at Tertiary Care Teaching Hospital over a period of 1 year. A cross sectional study consists of 180 subjects out of them 90 normal healthy subjects control Group (Group I) and 90 patients with type 2 DM with poor glycemic control were selected. Subjects were recruited according to simple random sampling method meeting the selection criteria. Group I – Control group (n=90): This group consisted of age and sex matched healthy subjects. They were taken from general population who came for routine checkup. Group II – Type 2 DM patients with poor glycemic control (n=90) this group consisted of patients with type 2 DM with duration more than 5 years, HbA1c Level >7%. Results: Characteristics like age, sex, were not differing between groups. We found increased serum alanine transaminase (ALT) and aspartate transaminase (AST) concentration in group II compared to group I. But serum alkaline phosphatase (ALP) concentration is significantly increased between groups (p value is <0.001 is considered significant). In our study shows that in group I Mean serum ALP (144.13±18.52) and hsCRP (1.35±0.20) when compared to group II serum ALP (147.23±25.95) and hsCRP (4.55±0.79). Conclusion: The present study suggests that serum ALP and hsCRP concentration is significantly increased in type 2 diabetes mellitus. Both are further increased in diabetic patients with complications and poor glycemic control. There is a significant positive correlation between serum ALP activity and hsCRP. Serum ALP level and hsCRP concentration was independently and positively correlated with FBS, PP2BS and HbA1c (markers of glycemic control). All these finding suggesting a link between CVD, inflammation and glycemic control in patient with type 2 diabetes mellitus.

Description