Abstract

The cause of the chronic multisystem illness known as rheumatoid arthritis is unknown. The hallmark of RA is persistent inflammatory synovitis, which typically affects the peripheral joints in a systemic distribution, despite the disease's wide range of systemic manifestations. The hallmark of the diseases is the potential for synovial inflammation to result in bone erosion and cartilage damage, which would then alter the integrity of the joints. Aim and Objectives: To study the serum levels of calcium and phosphorus and their ratio in Rheumatoid Arthritis patients. Materials and Methods: This is a prospective, comparative study in which 100 RA patients and 100 healthy persons without RA as controls were included in this study. The serum levels of calcium and phosphorus were studied and compared for both the groups. Results:Serum levels of calcium and calcium/phosphorus ratio were decreased and the estimated serum Calcium/Phosphorus ratio in cases is 1.62±0.25 as compared to control 2.75± 0.75. Conclusion: The decrease in the ratio of calcium to phosphorus in the blood suggests that RA patients have abnormal metabolisms of these both elements.

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